Usually when we talk about Republican obstruction, it’s to explain the immediate problems that need to be fixed, but can’t because Republican Senators won’t let the solutions come up for a vote—an understaffed Department of Justice, empty seats languishing on the federal judiciary, an impending budget deadline, etc.
Currently, for example, there are 34 judicial nominees pending on the Senate floor, the vast majority of which are to fill vacancies deemed “judicial emergencies.” 26 of those nominees have faced no Republican opposition; one received only one negative vote - but all of them are held up anyway, waiting endlessly to start their new jobs.
But perhaps the most damaging effect of this delay won’t become apparent for years. Delaying simple confirmation votes forces nominees to put their lives on hold for months or even years, for a job with longer hours and less pay than they could find elsewhere. The excruciatingly long confirmation process is making it harder and harder to recruit qualified candidates to fill critical government positions.
Already, some nominees have decided that they couldn’t, or didn’t want to, deal with the ugly process any longer.
Dawn Johnsen, President Obama’s pick to head the Office of Legal Counsel, eventually withdrew her name because Republican senators so politicized her nomination that they undermined her primary goal of depoliticizing the OLC itself. Mary Smith, nominated to head the Tax Division of the Justice Department, asked for her name to be withdrawn when she concluded GOP obstruction would drag on for months longer. And any number of judicial nominees have displayed borderline heroism by sitting by silently as their reputations are smeared by critics playing fast and loose with the truth. 
After seeing the treatment that even exceedingly well qualified nominees receive from the Senate, should it be any surprise if well qualified individuals in the future just decide that they don’t want the trouble?
Of course, if you’re in the business of attacking the Obama Administration at all costs , maybe scaring off qualified government officials isn’t a problem, it’s the goal.